Industry Overview

Patient’s choice for an infection free recovery is of critical importance worldwide. Despite improvements in HIV and HCV and HBV serological tests in recent years, instances of viral transmission via transfusion still occur.

Individual Donor Nucleic Acid Testing (ID-NAT) is a method of testing blood that is more sensitive than conventional tests that require the presence of antibodies to trigger a positive test result. ID-NAT significantly reduces the 'window period' or the time between donor exposure to the virus and the appearance of antibodies. By decreasing the window period, it allows for earlier detection of the infection and thus further decreases the possibility of transmission via transfusion. ID-NAT also detect mutants, occult cases and false negatives from serology.

Need for NAT

Reasons for implementing Individual Donor Nucleic Acid Testing (ID-NAT):

  • Substantial reduction of Window Period by ID-NAT.
  • India General Population - 25 lakhs with HIV, I crore 50 lakhs with HCV, and 4 crore 30 lakhs with HBV.
  • Currently the seroprevalence of anti-HIV-1, anti-HCV, and HBsAg in Indian blood donors is 0.5%, 0.4%, and 1.4%, respectively 1 compared to 0.0097%, 0.3%, and 0.07% for the 3 viruses in U.S. blood donors.
  • Reports of Occult HBV infections which HBsAg does not detect.
  • More than 50% of Blood donors are replacement donors and not Voluntary. Very little concept of repeat voluntary blood donation
  • Sensitivity of mandatory Serological Kits differs among different blood banks
  • Patient Safety
  • News and Public Outcry
  • Litigation
  • Achieving International Standard in Blood safety
  • Medical Tourism
  • Objective of using ID-NAT: To reduce the serological Window Period and provide near zero risk Blood
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